Midway through the series, GMA Network management announced that Trillo would be pulled out from the said show to once again star in another fantasy-themed television series Majika, in the end Trillo was allowed to complete Etheria.He also starred in the horror-suspense film Pamahiin and was included in the network's noontime show SOP as a co-host where he also played drums as part of the show's "Starband".Trillo released his self-titled debut album in 2007 under Indi Music.It was in the same year when he made his fourth Lenten drama special for GMA Network under APT Entertainment entitled Unico Hijo.He appeared in Sine Novela Presents: Gumapang Ka Sa Lusak opposite Jennylyn Mercado and portrayed Andrew Tantoco in the Philippine adaptation of the hit Korean series Endless Love.In 2011, Trillo appeared in the romantic-fantasy series Dwarfina where he teamed-up with Heart Evangelista.Trillo was born to Florita Florencio Ho, a Filipino, and Abelardo Leslie Ho, a Chinese Filipino from Dumaguete, Negros Oriental on May 12, 1981 in Quezon City.
He also had a weekly medical drama with Bela Padilla entitled Sa Puso ni Dok under GMA News & Public Affairs department.
The following year, 2005, Trillo officially became a leading man when he was paired with Angel Locsin in the television adaptation of the iconic superhero Darna.
He also starred in an afternoon family drama Now and Forever: Agos where he received a Best Drama Actor nomination from PMPC Star Awards for TV.
On August 21, 2007, he started taping for the fantasy series Zaido: Pulis Pangkalawakan with Aljur Abrenica and Marky Cielo.
The same year, Trillo joined the stellar cast of Magdusa Ka, an afternoon soap opera which later earned an International Emmy nomination the following year.
Heart and Daniel ended their relationship in 2012 after one and a half years dating.