In a radiolabeled study, unchanged buspirone in the plasma accounted for only about 1% of the radioactivity in the plasma.
Following oral administration, plasma concentrations of unchanged buspirone are very low and variable between subjects.
Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when tested in preclinical models.
This shift in chloride ions results in hyperpolarization (a less excitable state) and stabilization.Please see package insert for additional information and possible updates.The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.It also lacks the prominent sedative effect that is associated with more typical anxiolytics.In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT1A) receptors.Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.