In 2007, she became the first Serbian player to win a Grand Slam title when she won the Wimbledon mixed doubles title with British partner Jamie Murray.
In October 2003, Janković entered the top 100 at no.
Three months later, Janković garnered her first top-10 win against Elena Dementieva in the first round of the 2004 Australian Open. Elsewhere in her 2004 season, she defeated top-20 players Nadia Petrova (twice), Vera Zvonareva, Patty Schnyder, Elena Dementieva and Paola Suárez. Janković then lost in the final to Lindsay Davenport in three sets.
Janković was the fourth seed at the French Open and one of the favorites for the title.
After registering her third consecutive victory over Venus Williams in the third round, she went on to reach the semifinals of a Grand Slam for the second time in her career, but lost there to eventual champion Henin.
Janković, suffering from a hamstring injury, lost the final to Anna Chakvetadze.
At Wimbledon, Janković was the third seed, but lost in the fourth round to the surprise eventual finalist Marion Bartoli.
In May, Janković won her first WTA title, a Tier V event, in Budapest, defeating Martina Suchá in the final. She made her first Tier I semifinal in Berlin, losing to Nadia Petrova.